Ninevah Therapeutics

A cure for genetic forms of nephrotic syndrome

Disease


Disease
Nephrotic syndrome (NS) is a collection of symptoms due to kidney damage.
NS is defined as heavy proteinuria severe enough to cause hypoalbuminemia, edema, and hypercholesterolemia.

  • The second most frequent cause of end-stage kidney disease (ESKD) in children.
  • 20% of patients become resistant to steroids (SRNS) and only ~20-30% of pediatric patients are steroid-sensitive.
  • SRNS leads to end stage renal disease (ESRD), the last stage of chronic kidney disease (CKD) in more than 50% of patients.
  • 30% of cases (or more) of SRNS are caused by mutations of genes.
  • Genetic forms of NS affects 1 to 3 per 100,000 children worldwide.

The features of nephrotic syndrome are caused by failure of the kidneys to filter waste products from the blood and remove them in urine. Signs and symptoms of this condition are excessive protein in the urine (proteinuria), increased cholesterol in the blood (hypercholesterolemia), an abnormal buildup of fluid in the abdominal cavity (ascites), and swelling (edema). Affected individuals may also have blood in the urine (hematuria), which can lead to a reduced number of red blood cells (anemia) in the body, abnormal blood clotting, or reduced amounts of certain white blood cells. Low white blood cell counts can lead to a weakened immune system and frequent infections in people with congenital nephrotic syndrome.

Children with genetic forms of nephrotic syndrome typically develop end-stage renal disease between ages 2 and 8, although with treatment, some may not have kidney failure until adolescence or early adulthood.

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition

Unfortunately, there is no specific treatment available.

Company


Company
Ninevah Therapeutics (NTX) is a biotech company developing novel medicines for genetic forms of nephrotic syndrome

NTX is the first company to develop a gene therapy to cure nephrotic syndrome

Our mission: to generate value by successfully complete a Phase 2a trial with our leading program.

NTX was founded in Barcelona Q2-2019

Contact


  • Carrer de Baldiri Reixac, 4, Barcelona, Spain

Jobs


R&D Project Manager – Postdoctoral Scientist – Renal Biology / Gene Therapy - Barcelona, Spain

The company is looking for an exceptional scientist to lead discovery research with special emphasis on understanding gene therapy for renal diseases.

Ninevah Therapeutics (NTX) is a discovery company developing gene therapies for kidney orphan diseases. Our lead program is an AAV-based therapy for genetic nephrotic syndrome (NTX014). NTX mission is to translate NTX014 from discovery to a first-in-human trial (Phase 2a).

A postdoctoral position is available for a highly motivated and creative scientist interested to be part of this just launched biotech company. The successful candidate will join an entrepreneurial team and will collaborate with top researchers and advisors.

The ideal candidate should enjoy building an early-stage biotech company, partnering with academic institutions and open to embrace a wide variety of projects out of the lab.

This position starts in March 2020 and it is based in Barcelona.

  • PhD in Biomedical/Cell and Molecular Biology or related fields.
  • Research experience in Renal Biology highly preferred.
  • Recommended research experience includes protein biochemistry, disease model generation, cellular assay development, genomics and/or cell imaging systems.
  • Demonstrated ability to be highly productive in a fluid, fast-paced and teamwork environment.


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